Juande Ramos has signed a four-year deal to become the new head coach of Tottenham Hotspur, replacing Martin Jol who was sacked on Thursday.
Ramos, 53, resigned as Sevilla coach on Friday and Spurs have asked Leeds if they can invite Gus Poyet to work as Ramos's assistant.
Ramos said: "It is a squad any coach would be excited to work with. There is the potential to achieve great things."
Newspaper reports suggest he will be paid up to £6m a year by Spurs.
Ramos will be at White Hart Lane for Sunday's Premiership clash with Blackburn and will take charge of Spurs for the first time for Wednesday's Carling Cup visit of Blackpool.
Tottenham must now negotiate a pay-off to Jol and a compensation package for Sevilla.
Ramos led Sevilla to the Uefa Cup title in each of the last two seasons and into the Champions League for the first time after they finished a close third behind Real Madrid and Barcelona last year.
He also won a European Super Cup, a Copa del Rey and a Spanish Super Cup for the Andalusian club.
"This has been the hardest decision of my life," he said after leaving the Spanish club.
"My time at Sevilla has been the most important period of my life personally and professionally. I will be eternally grateful."
And in a statement released through the Tottenham website, he added: "I greatly appreciate the opportunity to work as head coach at Tottenham Hotspur, a club with a great tradition and history.
"Ever since I started my coaching career I have wanted to work in England. It is my sincere hope that I can repay the faith the Spurs board has shown in me.
"I am looking forward to meeting the players.
"I was hugely impressed with the Spurs fans both home and away when Sevilla played Spurs last season and it will be a privilege to be the coach of this club with the huge support it enjoys both at White Hart Lane and throughout the world."
Marcos Alvarez, 36, who worked with Ramos at Sevilla, will also join the Tottenham coaching staff.
Ramos's contract with Sevilla had been due to expire at the end of this season and Manolo Jimenez has been promoted from youth team coach to replace Ramos until the end of the season.
Spurs sporting director Damien Comolli said: "Juande's arrival is great news for Tottenham Hotspur.
"He brings with him a wealth of experience, a proven track record and a winning pedigree.
"Now is the time for us to regroup and look to deliver the results and performances that everyone associated with the club wants to see."
Ramos's appointment brings to an end a lengthy pursuit by Spurs.
They were revealed to be interested in recruiting the Spaniard in the first week of the season when officials met him at the Alfonso XIII hotel in Sevilla.
He steps into the vacancy left by Jol, who was sacked following a disappointing start to the season which has left Spurs third from bottom.
Juan de la Cruz Ramos Cano
Barcelona B (1996-97)
Rayo Vallecano (1998-01)
Real Betis (2001-02)
Trophies: Uefa Cup (2005, 2006)
Super Cup (2006)
Copa del Rey (2007)
Spanish Supercopa (2007)